Due to its potential to virilize women, testosterone therapy for osteoporosis has not been thoroughly researched in female patients. Gender dysphoric females who take supraphysiologic doses of testosterone to change from a female to a male phenotype are known as female-to-male epicene. Examining the effects of testosterone therapy on the genetic female skeleton is the goal of this study.
Up until recently, short-acting testosterone esters like testosterone cypionate and enanthate, which typically cause supraphysiological peaks and hypogonadal troughs in testosterone levels, were frequently used by intramuscular injection. A “roller coaster” effect, which corresponds to the fluctuations in serum testosterone levels, can also happen. It is characterised by alternating periods of symptomatic benefit and a return to baseline symptoms. Clinical trial data do not support the recommendation of testosterone supplementation for cardiovascular health, sexual function, physical function, mood, or cognitive function in men with “low T,” the researchers conclude.
Men are known to experience an increasing incidence of testosterone deficiency as they age. Men’s quality of life and perception of their general health are negatively impacted by the clinical signs and symptoms of low testosterone. An area for potential intervention is the interaction of androgen deficiency and chronic systemic disease. The best testosterone booster supplements for raising testosterone in men are as follows:
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In order to clarify the pathophysiology of androgen deficiency of chronic disease and discuss whether intervention, such as testosterone replacement and organ transplantation, improve patient outcomes and quality of life, we here explore the topic of testosterone deficiency among men with end-stage organ failure needing transplantation.
There is a substantial body of evidence that suggests androgen deficiency plays a role in the development, progression, or both of cardiovascular disease (CVD). This review’s objectives are to assess the connections between low levels of testosterone (T) and CVD risk factors and to talk about the implications of androgen deficiency in men with cardiovascular risk factors. Regarding CVD, it is discussed how androgen deficiency affects endothelial function, lipid profiles, inflammatory reactions, altered vascular smooth muscle reactivity, and hypertension.
Endothelial dysfunction is exacerbated by androgen deficiency, which is also linked to higher levels of total cholesterol, low-density lipoprotein, proinflammatory cytokines, and arterial wall thickness. In addition to improving endothelial function and restoring arterial vasoreactivity, testosterone supplementation also lowers levels of high-density lipoprotein and of proinflammatory cytokines, total cholesterol, and triglycerides.